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Publications

Top 3 Publications

1. F. Haamedat, B. Mendes, J. Conniot, L. D. Di Filippo, M. Chorilli, A. Schroeder, J. Conde*, F. Sousa*, Engineered nanomaterials for glioblastoma nanovaccination,  Nat Rev Mat, 2024

2. F. Sousa et al, Enhanced Anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles, J. Control Release, 2019, 22;309:37-47

3. F. Sousa*, H. Lee, M. Almeida, A. Bazzoni, B. B. Rother-Rutishauser, A. Petri-Fink, Immunostimulatory nanoparticles delivering cytokines as a novel cancer nanoadjuvant to empower glioblastoma immunotherapy, Drug Deliv Transl Res, 2023

  1. F. Haamedat, B. Mendes, J. Conniot, L. D. Di Filippo, M. Chorilli, A. Schroeder, J. Conde, F. Sousa*, Engineered nanomaterials for glioblastoma nanovaccination, 2023, Nature Reviews Materials, 2024

  2.  F. Sousa, Emerging cytokine delivery with nanomedicine for brain cancer treatment, Expert Opinion on Drug Delivery, 2024 

  3. F. Sousa, Brain-Targeted Drug Delivery, Pharmaceutics 2022, 14(9), 1835

  4. F. Diniz, M. Azevedo, F. Sousa, H. Osório, D. Campos, P. Sampaio, J. Gomes, B. Sarmento, C. Reis, Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions, Materials Today Bio, 2022, 16, 100417

  5. F. Sousa, A.I. Costa-Pereira, A. Cruz, F.J. Ferreira, M. Gouveira, J. Bessa, B. Sarrmento, R.D.M. Travasso, I.M. Pinto, Intratumoral VEGF nanotrapper reduces glioblastoma vascularization and tumor cell mass, J Control Release, 2021, doi:10.1016/j.jconrel.2021.09.031

  6. J.M.W.D. Neto, J.C. Silva, F. Sousa, O.S.L. Gonçalves, M.C. A. Wanderley, B. Sarmento, C.A. Lima, M.T. Neves-Petersen, A. L. F. Porto, Structural and functional analysis of broad pH and thermal stable protease from Penicilium aurantiogriseum URM 4622, Preparative Biochem & Biotech, 2021, doi: 10.1080/10826068.2021.1972429

  7. B. Sánchez-Dengra, I. González-Álvarez, F. Sousa, M. Bermejo, M. González-Álvarez, B. Sarmento, In vitro model for predictiong the access and distribution of drugs in the brain using hCMEC/D3 cells, Eur. J. Pharm. Biopharm, 2021, 163: 120-126 doi:1016/j.ejpb-2021.04.002

  8. J. Finbloom, F. Sousa, M. M. Stevens, T.A. Desai, Engineering the Drug Carrier Biointerface to Overcome Biological Barriers to Drug Delivery, Adv. Drug Deliv. Rev., 2020, 167: 89-108

  9. A. Jaradat, M.H. Macedo, F. Sousa, K. Arkill, C. Alexander, J. Aylott, B. Sarmento, Prediction of the enhanced absorption of insulin across triple co-cultured model using mucus penetrating PLGA NPs, Inter. J. Pharm., 2020, 585:119516

  10. A. Baião, F. Sousa, A. Oliveira, C. Oliveira, B. Sarmento, Effective intracelular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells, Biomaterials Science, 2020, 8:3720-3729

  11. J.P. Martins, J. das Neves, M. de la Fuente, C. Celia, H. Florindo, N. Günday-Türeli, A. Popat, J. L. Santos, F. Sousa, R. Schmid, J. Wolfram, B. Sarmento, H. Santos, The solid progress of nanomedicine, Drug Deliv. and Transl. Res. 2020, 10(3): 726-729

  12. M. Qin, J. Jin, Q. Saiding, Y. Xiang, Y. Wang, F. Sousa, B. Sarmento, W. cui, X. Chen, In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic flood repair, J. Controlled Release, 2020, 322, 375-389.

  13. C. Pacheco, F. Sousa, B.Sarmento, Chitosan-based Nanomedicine for Brain Delivery: Where Are We Heading?, Reactive and Functional Polymers, Reactive and Functional Polymers, 2020, 146:104430

  14. J. Yang, F. Wang, Y. Lu, J. Qi, L. Deng, F. Sousa, B. Sarmento, Xiangyang Xua, Wenguo Cui, Recent advance of erythrocyte-mimicking nanovehicles: from bench to bedside, J. Control Release, 2019, 20; 314:81-91.

  15. F. Sousa, H.K. Dhaliwal, F. Gattacceca, B. Sarmento, M. Amiji, Enhanced Anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles, J. Control Release, 2019, 22;309:37-47

  16. R.P. Moura, C. Martins, F. Sousa, S. Pinto, B. Sarmento, Blood-Brain Barrier receptors and transporters: An insight on their function and how to exploit them though nanotechnology, Expert Opinion on Drug Delivery, 2019, 16(3):271-285

  17. N.N. Ferreira, B.L. Caetano, F.I. Boni, F. Sousa, M. Magnani, B. Sarmento, B.S.F. Cury, M.P.D. Gremião, Alginate-Based Delivery Systems for Bevacizumab Local Therapy: In vitro structural features and release properties, J. Pharm. Sciences, 2019, 108(4):1559-1658

  18. P. J. Kennedy, F. Sousa, D. Ferreira, C. Pereira, M. Nestor, C. Oliveira, P. L. Granja, B. Sarmento, Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6, Acta Biomater., 2018, 81:208-218

  19. I. Pereira, F. Sousa, P. Kennedy, B. Sarmento, Carcinoembryonic antigen-targeted nanoparticles potentiate the delivery of anticancer drugs to colorectal cancer cells, Int. J. Pharm., 2018, 549(1-2):397-403

  20. F. Sousa, A. Cruz, I.M. Pinto, B. Sarmento, Nanoparticles provide long-term stability of bevacizumab preserving its antiangiogenic activity, Acta Biomater., 2018, 78_285-295

  21. O. S. Silva, J. C. Silva, E. M. Almeida, F. Sousa, O.S.L. Gonçalves, B. Sarmento, M.T. Neves-Petersen, T. S. Porto, Biophysical, photochemical and biochemical characterization of a protease from Aspergillus tamarii URM4634, Int. J. Biol. Macromol., 2018, 118:1655-1666

  22. P. Castro, F. Sousa, R. Magalhães, V.M. Pizones Ruiz, A. M.R. Pilosof, A.R. Madureira, B. Sarmento, M. Pintado, Incorporation of beads into oral films for buccal and oral delivery of bioactive molecules, Carbohydrate Polymers, 2018, 194:411-421

  23. D. Sgorla, A. Lechanteur, A. Almeida, F. Sousa, E. Bunhak, R. Mainardesm N. Kahlil, O. Cavalcanti, B. Sarmento, Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery,  Expert Opin. Drug Deliv, 2018. 15(3):213-222

  24. A.R. Madureira, T. Atatoprak, D. Çabuk, R.C. Pullar, F. Sousa, M. Pintado, Extraction and characterization of celulose nanocrystals from pineapple peel, Int. J. Food Studies, 2017, 7(1)

  25. C. Martins, F. Sousa, F. Araújo, B. Sarmento, Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications, Adv. Healthc. Mater, 2017, 1701035

  26. F. Sousa, B. Sarmento, M. T. Neves-Petersen, Biophysical study of bevacizumab structure and bioactivity under thermal and pH-stresses, Eur. J. Pharm. Sci. 2017, 105, 127

  27. F. Sousa, V. M. F. Goncalves, B. Sarmento, Development and validation of a rapid reversed-phase HPLC method for the quantification of monoclonal antibody bevacizumab from polyester-based nanoparticles, J. Pharm. Biomed. Anal., 2017, 142, 17

  28. F. Sousa, A. Cruz, P. Fonte, I. M. Pinto, M. T. Neves-Petersen, B. Sarmento, A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles, Sci. Rep. 2017, 7, 3736

  29. F. Sousa, P. Castro, P. Fonte, P. J. Kennedy, M. T. Neves-Petersen, B. Sarmento, Nanoparticles for the delivery of therapeutic antibodies: Dogma or promising strategy?, Expert Opin. Drug Deliv. 2017, 14, 1163

  30. P. Castro, P. Fonte, F. Sousa, A.R. Madureira, B. Sarmento, M. E. Pintado, Oral films as breakthrough tools for oral delivery of proteins/peptides, J. Control. Release, 2015 Aug 10;211:63-73

  31. F. Sousa, P. Castro, P. Fonte, B. Sarmento, How to overcome the limitations of current insulin administration with new non invasive delivery systems, Ther. Delivery, 2015 Jan;6(1):83-94

  32. P. Fonte, S. Soares, F. Sousa, A. Costa, V. Seabra, S. Reis, B. Sarmento, Stability Study Perspective of the Effect of Freeze-Drying using Cryoprotectants on the Structure of Insulin Loaded into PLGA Nanoparticles, Biomacromolecules, 2014 Oct 13;15(10):3753-65

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Book chapters

  1. C. Pacheco, A. Baião, F. Sousa, Implantable and long-lasting drug delivery systems for cancer treatment, Long-Acting Drug Delivery Systems:Pharmaceuticial, Clinical and Regulatory Aspects, Elsevier, 2021, ISBN 9780128217498

  2. R.P. Moura, F. Sousa, A. Almeida, S. Pinto, B. Sarmento, Theranostic biomaterials for the regulation of the blood-brain barrier, in Theranostic Bionanomaterials, Edited by Wenguo Cui and Xin Zhao, Elsevier, ISBN 9780128153413, 2019

  3. F. Sousa, R.P. Moura, E. Moreira, C. Martins, B. Sarmento, “Therapeutic Monoclonal Antibodies Delivery for the Glioblastoma Treatment”, Adv. Protein Chem. Struct. Bio., 2018, doi: 10.106/bs.apcsb.2018.03.001

  4. F. Sousa, P. Fonte, A. Cruz, P.J. Kennedy, I.M. Pinto, B. Sarmento, “Polyester-Based Nanoparticles for the Encapsulation of Monoclonal Antibodies”, Methods Mol. Biol. 2018, 1674, 239.

  5. P. Fonte, F. Sousa, B. Sarmento, “Polyester-Based Nanoparticles for Delivery of Therapeutic Proteins”, Methods Mol. Biol. 2018, 1674, 255.

  6. F. Sousa, P. Castro, Cell-based in vitro models for nasal permeability studies, Concepts and Models for Drug Permeability Studies, Elsevier, 2016, 83-100, doi: 10.1016/B978-0-08-100094-6.00006-7

  7. F. Sousa, P. Fonte, B. Sarmento, Effect of lipid matrix on structure and stability of protein-loaded solid lipid nanoparticles and nanostructured lipid carriers, Future Medicine, 2015, doi: 10.4155/fseb2013.14.12

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